The Immunological Barriers to Regenerative Medicine [Paperback]

This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.This book analyzes immunological issues facing regenerative medicine, showing how allograft rejection applies to cell replacement therapy, addressing issues of immunogenicity and exploring novel approaches to the induction of immunological tolerance.

Mechanisms of Immune Rejection of Stem Cell-Derived Tissues: Insights from Organ Transplantation.- The Immunogenicity of ES Cells and their Progeny.- Interaction of Embryonic Stem Cells with the Immune System.- The Role of NK cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues.- Mitigating the Risks of Immunogenicity in the Pursuit of Induced Pluripotency.- Thymic Involution: A Barrier or Opportunity for Cell Replacement Therapy?.- Construction of Stem Cell Banks: Prospects for Tissue Matching.- Generation of Histocompatible Tissues via Parthenogenesis.- Prospects for Designing Universal Stem Cell Lines.- The Immunosuppressive Properties of Adult Stem Cells: MSC as a Case Study.- The Immunogenicity of Stem Cells and Thymus-Based Strategies to Minimise Immune Rejection.- The Induction of Mixed Chimerism Using ES Cell-Derived HematolóÆ