This thoroughly revised and updated new edition provides outstanding coverage of the most important aspects of immunology. Assuming no previous knowledge of the subject, the book gives step-by-step detail on topics such as antigens, hypersensitivity, autoimmunity, reproductive immunity and immunodeficiency. There is an accompanying website with supplementary material.
Preface. Preface to the 1st Edition.
Glossary.
1 Cells and tissues of the immune system.
1.1 Cells involved in the immune response.
1.1.1 Cellular origins – the pluripotent stem cell.
1.1.2 Cells principally involved in the innate immune response.
Polymorphonuclear leukocytes.
Neutrophils.
Eosinophils.
Basophils and mast cells.
Megakaryocytes and platelets.
1.1.3 Antigen presenting cells and large granular lymphocytes.
Monocytes and macrophages.
Dendritic cells.
Large granular lymphocytes.
1.1.4 Cells involved in the specific immune response.
Lymphocytes.
T cells.
B cells.
Key points for review.
1.2 Lymphoid tissues.
1.2.1 Primary lymphoid tissues.
The thymus.
Mammalian bursa equivalents .
B cell development in the bone marrow.
1.2.2 Secondary lymphoid tissues.
The lymphatic system.
Lymph nodes.
Spleen.
1.2.3 Tertiary lymphoid tissues.
Mucosa-associated lymphoid tissue.
Intraepithelial lymphocytes.
Key points folCŸ