Immunoreceptor Tyrosine-based Inhibition Motifs [Paperback]

Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.List of Contents.- Biology of Immunoreceptor Tyrosine-based Inhibition Motif-Bearing Molecules.- Negative Regulation of Hematopoietic Cell Activation and Proliferation by Fc?RIIB.- The Role of the SRC Homology 2-Containing Inositol 5?-Phospatase in Fc?Rl-Induced Signaling.- The Unexpected Complexity of Fc?RIIB Signal Transduction.- Regulation of B Cell Antigen Receptor Signaling by the Lyn/CD22/SHP1 Pathway.- HLA-Specific and Non-lÓ,