Influenza Pathogenesis and Control - Volume I [Hardcover]

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.?

Part I: Molecular determinants of pathogenicity

?The Hemagglutinin - a Determinant of Pathogenicity

Eva B?ttcher-Friebertsh?user, Wolfgang Garten, Mikhail Matrosovich, and Hans Dieter Klenk

?Molecular determinants of pathogenicity in the polymerase complex

G?lsah Gabriel and Ervin Fodor

?Part II: Virus entry and cell tropism

?Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range

Xiaoli Xiong, John W. McCauley, David A. Steinhauer

?Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology

Charles J. Russell

Part III: Transmission and Pandemics

?Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT)

Nancy J. Cox, Susan C. Trock and Stephen A. Burke

?Avian influenza virus transmission to mammals

S. Herfst, M. Imai, Y. Kawaoka anló-