Interaction Between Neurons and Glia in Aging and Disease [Paperback]

A superb source of reference reviews as well as a concise overview of the functional cross-talk between neurons and glial cells, this book also focuses on microglia and inflammation in the aging brain and in neurological disorders. The scientific spectrum covered by this book is of key interest, and is recognized by the scientific community as a major competitive area with critical implications for human health.

Interactions Between Neurons and Glia in Aging and Disease is a source of reference reviews and concise overviews of the functional cross-talk between neurons and glial cells, with a focus on microglia and inflammation in the aging brain and in neurological disorders. The scientific area covered by this book may be considered of key interest, and it is recognized, by the scientific community, as a major competitive area with critical implications for human health.

This book is organized in three main sections that are expected to guide the readers from the basic functional cross-talk between neuron and glia to brain pathology. The specific proposed sections are: 1) Neuroimmunity and Neuroinflammation; 2) Signalling and inflammation in aging; 3) Neurodegeneration and inflammation in age related diseases.

Neuroimmunity and neuroinflammation.- Inflammation and Neuronal Susceptibility to Excitotoxic Cell Death.- Microglial Cell Population Expansion Following Acute Neural Injury.- Opposite Modulation of Peripheral Inflammation and Neuroinflammation by Adenosine A2A Receptors.- Subventricular Zone Cells as a Tool for Brain Repair.- Signaling and inflammation in aging.- Neuron-Glia Interaction in Homeostasis of the Neurotransmitters Glutamate and GABA.- The Impact of an Imbalance Between Proinflammatory and Anti-inflammatory Influences on Synaptic function in the Aged Brain.- Neurotrophin Signaling and Cell Survival.- GDNF: a Key Player in Neuron-Glia Crosstalk and Survival of Nigrostriatal Dopaminergic NeurlG