Introduction to Modeling Biological Cellular Control Systems [Hardcover]

This textbook contains the essential knowledge in modeling, simulation, analysis, and applications in dealing with biological cellular control systems. In particular, the book shows how to use the law of mass balance and the law of mass action to derive an enzyme kinetic model - the Michaelis-Menten function or the Hill function, how to use a current-voltage relation, Nernst potential equilibrium equation, and Hodgkin and Huxley's models to model an ionic channel or pump, and how to use the law of mass balance to integrate these enzyme or channel models into a complete feedback control system. The book also illustrates how to use data to estimate parameters in a model, how to use MATLAB to solve a model numerically, how to do computer simulations, and how to provide model predictions. Furthermore, the book demonstrates how to conduct a stability and sensitivity analysis on a model.

Here is essential coverage of modeling, simulation, analysis and applications dealing with biological cellular control systems. Shows how to use data to estimate parameters, and use MATLAB for simulations, predictions and stability and sensitivity analysis.

Enzyme Kinetics.- Preliminary Systems Theory.- Control of Blood Glucose.- Control of Calcium in Yeast Cells.- Kinetics of Ion Pumps and Channels.- Store-Operated Calcium Entry.- Control of Mitochondrial Calcium.- Control of Phosphoinositide Synthesis.- PreliminaryMATLAB.

From the reviews:

This book addresses the modeling, simulation, analysis and control of biochemical processes of systems arising in cellular biology. & The book is very well written in an-easy way to grasp the essential elements of the various topics. Further, the book provides the necessary introductory material on control systems and MATLAB useful for those with background in cellular biology only. This book is a welcome addition to this growing interdisciplinary field & . (D. Subbaram Naidu, Amazon.com, November, 2013)lS¥