Introduction to Molecular Medicine [Paperback]

This updated and revised third edition explains the fundamental principles of the human genome, gene regulation and expression, and genetic engineering. Principles are then applied to the diagnosis and treatment of human disease in infectious diseases, inherited genetic diseases, the immune system and blood cells, cancer, and public health. The text presents the basics of molecular biology and its impact on medicine in a user-friendly, concise, conversation format, with new discussions on the human genome project and genetic engineering. Ross'Introduction to Molecular Medicine remains a must-have information source for all physicians, residents, and medical students.This book continues the story of a new field called molecular medi? cine. The first edition appeared 10 years ago in a previous millennium. At that time cloning a gene was cutting edge research; now gene cloning is a high school science fair project. The complete sequencing of the human genome was finished last year; cloning a human is a likely (and very controversial) event for 2002. The tools of molecular medicine have become very powerful and automated; DNA on a chip and microarrays allow us to probe large parts of the genome and its function. The speed of sequencing DNA has increased about 100,0- fold over the decade since the first edition of this book was published. Following the great improvements in technology, DNA and molecular research have a rapidly deepening impact on human medicine. Molec? ular therapies including DNA vaccines, antisense, and gene transplan? tation are undergoing clinical trials.PART I: Basics of Molecular Biology. 1. Human Genome, 2. Gene Regulation and Expression, 3. Genetic Engineering. PART II: Molecular Approach to Disease. 4. Infectious Disease, 5. Inherited Genetic Diseases, 6. Immune System and Blood Cells, 7. Cancer, 8. Molecular Therapeutics. Conclusions. Glossary. Index.

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Well written... presented in a style thal.