Ionizing Radiation Part II Some Internally Deposited Radionuclides [Paperback]

This monograph evaluates the evidence for carcinogenicity of ionizing radiation from internally deposited radionuclides. The radionuclides considered in this monograph belong to two broad categories: those that emit a-particles (helium nuclei) and those that emit b-particles (electrons) during their primary radioactive decay.

For purposes of this monograph 'internally deposited' refers to radionuclides in dispersed forms (e.g. dusts suspensions solutions or gases) that enter the body through inhalation ingestion by some form of injection or in some cases by percutaneous absorption. Radionuclides may also enter tissues within removable objects, such as radioactive beads needles etc. that may be implanted surgically for therapeutic purposes or other kinds of fragments implanted accidentally. These kinds of exposures are not considered in this volume. Also not considered are radionuclides (e.g. iron-55 gallium-67) which undergo radioactive decay through processes that do not include emission of either a or b particles.

Radon and its decay products were previously evaluated in IARC MonographsVolume 43 (1988) as carcinogenic to humans(Group 1). The subsequently published scientific literature on occupational and residential exposures to radon was reviewed and included in this volume as an update but no re-evaluation of radon was considered necessary.

Six specific radionuclides of the elements radium thorium plutonium and phosphorus plus mixed radionuclides of iodine were evaluated as carcinogenic to humans (Group 1) on the basis of sufficient evidence for increased risk of cancer in exposed individuals. These include radium-224 radium-226 radium-228 thorium-232 (administered in colloidal form as thorium-232 dioxide) plutonium-239 (exposure to which also entails exposure to plutonium-240 and other isotopes of plutonium) radioisotopes of iodine including iodine-131 anl“+