Polyploidization and Cancer [Hardcover]

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overviewsubjects relating to polyploidization and cancer.This book reviews the growing body of evidence indicating that surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Leaders in the field contribute an expert overview on subjects relating to polyploidization and cancer.Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overviewsubjects relating to polyploidization and cancer.1. Polyploidy, Aneuploidy and the Evolutionof Cancer.................. 1Lauren M. F. Merlo, Li?san Wang, John W. Pepper, Peter S. Rabinovitchand Carlo C. MaleyAbstract.................... 1Introduction................... 1The Tetraploidy to Aneuploidy Progression in Carcinogenesis................. 1Tetraploidy and Aneuploidy in Barretts Esophagus................ 2Not All Aneuploids Are Equal................. 4Why Do Cancer Cells Survive with Such Massive Alterations to Thlãr