With contributions by numerous experts1. Histology of the enteroehromaffin cell system.- I. Introduction.- II. The elements of the enterochromaffin cell system.- III. Histochemical characteristics of 5-HT of diagnostic importance.- A. Fixability characteristic.- B. Colour reaction.- 1. Chromaffin reactio.- 2. Argentaffin reactions and argentophil.- 3. Diazo reaction.- 4. Pearses thyo-indoxyl reaction.- 5. Other reactions.- 6. Reactions which do not give the expected positive response.- 7. Various procedures.- C. Fluorescence as a diagnostic criterion.- D. Limits of histochemical diagnosability of 5-HT.- E. Histochemical data obtained by destructive extra-situm methods.- IV. The enterochromaffin cell syste.- A. Enterochromaffin cells.- 1. The typical enterochromaffin cell.- a) Specific granules.- ?) Histochemical characteristics.- ?) Histophysical characteristics.- ?) Ultrastructural data.- ?) Data obtained by homogenization and differential centrifugation.- b) Topographical distribution.- ?) Intestinal distribution.- ?) Extra-intestinal localization.- c) Taxonomical distribution.- 2. Brief notes on the argentophil pre-enterochromaffin cells.- 3. Embryology of the enterochromaffin cell.- a) Time of appearance of the enterochromaffin cell.- b) Experimental embryological data.- c) Origin of the enterochromaffin cell.- 4. Various functional conditions of the enterochromaffin cell.- B. Chromaffin cells of the posterior salivary glands of Octopoda.- C. Chromaffin cells in the hypobranchial gland of Muricidae.- D. Cutaneous poison glands in Amphibians.- E. Chromaffin cells in Calliactis parasitica.- F. Poison gland cells of some scorpions.- G. Mast cells in the rat and the mouse.- V. Localizations of phenolic and indolic substances which cannot be referred to 5-H.- VI. Localizations of 5-HT which cannot be histochemically demonstrated.- VII. Final considerations.- VIII. Technical appendix.- A. Fixations.- 1. Formalin fixation.- 2. Freezing drying.- 3. Fixation for electrol#Ñ