Allosteric Regulatory Enzymes [Paperback]

This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.

This book covers the most recent developments in the analysis of allosteric enzymes. It provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life.

All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by more than a billion fold. Allosteric enzymes are even more amazing because they have the additional ability to change their rate in response to cellular activators or inhibitors. This enables them to control the pathway in which they are the regulatory enzyme. Since the effector molecules represent the current status of the cell for a given metabolic pathway, this results in very responsive and balanced metabolic states, and makes it possible for cells and organisms to be appropriately dynamic, and responsive, in a changing environment. This book provides a logical introduction to the limits for enzyme function, as dictated by the factors that are the limits for life. This book presents a complete description of all the mechanisms used for changing enzyme activity. Eight enzymes are used as model systems, because they have been studied extensively. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.

While authors often emphasize the few enzymes that have the most remarkable catalytic rl3'