Important clinical issues as the outcome of long term treatment withantidepressants, the time of onset of the antidepressant response andthe limitations of the antidepressants currently available are coveredin this monograph. Leading researchers in the area of clinical andexperimental psychopharmacology critically assess the progress in theirspecialist fields. The mechanisms of action of antidepressants areconsidered, followed by clinical research into the role of thehypothalamic-pituitary-adrenal axis and the immune system in the biologyof depression and in response to treatment. The final chapter deals withthe important chemical entities now undergoing development asantidepressants. The purpose of this monograph is not only to inform butalso to stimulate research into the biology of depression and themechanisms behind the action of effective antidepressants.This monograph is of interest to psychiatrists, psychologists,pharmacologists, neuroscientists and endocrinologists.Important clinical issues as the outcome of long term treatment withantidepressants, the time of onset of the antidepressant response andthe limitations of the antidepressants currently available are coveredin this monograph. Leading researchers in the area of clinical andexperimental psychopharmacology critically assess the progress in theirspecialist fields. The mechanisms of action of antidepressants areconsidered, followed by clinical research into the role of thehypothalamic-pituitary-adrenal axis and the immune system in the biologyof depression and in response to treatment. The final chapter deals withthe important chemical entities now undergoing development asantidepressants. The purpose of this monograph is not only to inform butalso to stimulate research into the biology of depression and themechanisms behind the action of effective antidepressants.This monograph is of interest to psychiatrists, psychologists,pharmacologists, neuroscientists and endocrinologists.Clinical issues.- Long-tl“Ü