Biochemistry of Atherosclerosis [Paperback]

This book covers many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. It includes all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. Also explored are the roles of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. The book further discusses how genetic studies can help understand the complexities that mediate these aspects of atherogenesis.

At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. This book will explore the role of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. Finally, how the use of genetic studies can help sort out the immense complexities that mediate these aspects of atherogenesis will be discussed.

The role of HDL in the prevention of atherosclerosis.- Cholesterol breakdown and the significance in atherosclerosis.- Triacylglycerol hydrolase, VLDL assembly and development of atherosclerosis.- Regulation of Hepatic Production of Lipoproteins Containing Apolipoprotein B and the significance in atherosclerosis.- Dyslipidemia and thrombogenesis.- Mouse models of Diabetes and Atherosclerosis.- Role of the unfolded protein response in atherosclerosis: a potential unifying theory of atherogenesis.- SR-BI, reverse cholesterol transport and atherogenesis.- Hypertension and atherosclerosis.- Dietary fats, transcription factors and heart health.- Dietary fatty acid intake and stroke.- Homocysteine metabolism and atherosclerosis.- Vitamin slók