Biochemistry of Biogenic Amines [Paperback]

1 Enzymes Involved in the Biosynthesis and Degradation of Catecholamines.- 1. Catecholamine Biosynthesis.- 2. Enzymes Involved in the Biosynthesis of Catecholamines.- 2.1. Tyrosine Hydroxylase.- 2.2. Dihydropteridine Reductase.- 2.3. Dopa Decarboxylase.- 2.4. Dopamine-?-hydroxylase.- 2.5. Phenylethanolamine-N-methyltransferase.- 3. Enzymes Involved in Catabolism of Catecholamines.- 3.1. Monoamine Oxidase.- 3.2. Catechol-O-methyltransferase.- 4. References.- 2 Release of Catecholamines.- 1. Introduction.- 2. Release From Adrenergic Neurons.- 2.1. Anatomical and Physiological Characteristics of Adrenergic Nerves.- 2.2. Mechanisms of Release: The Exocytosis Hypothesis.- 2.3. Importance of Ca2+ in Release; Effects of Other Ions.- 2.4. Regulation of Release.- 2.5. Pharmacological Aspects of the Storage and Release of NE.- 2.6. False Neurotransmitters.- 3. Release from Central Adrenergic Neurons.- 3.1. Release from the Brain in Vivo.- 3.2. Release from CNS Tissues in Vitro.- 4. Conclusions.- 5. References.- 3 Properties and Functions of Intraneuronal Monoamine Compartments in Central Aminergic Neurons.- 1. Introduction.- 2. One or Several Storage Compartments for Monoamines?.- 3. Utilization of Monoamines in Aminergic Terminals.- 3.1. Disappearance Curves for Radioactive Monoamines.- 3.2. Initial Accumulation of Newly Synthesized Amines.- 3.3. Initial Rate of Disappearance of Catecholamines After Inhibition of Their Synthesis.- 4. Relation of Storage Compartments to Amine Release.- 4.1. Noradrenergic Neurons.- 4.2. Serotoninergic Neurons.- 4.3. Dopaminergic Neurons.- 5. Functional Implications of Storage Compartments in Aminergic Neurons.- 5.1. Effects of Reserpine.- 5.2. Effects of Synthesis Inhibitors.- 6. Conclusions.- 7. References.- 4 5-Hydroxytryptamine and Other Indoles in the Central Nervous System.- 1. Occurrence of 5-Hydroxytryptamine in Central Nervous System.- 2. Pathway of 5-Hydroxytryptamine Synthesis.- 2.1 Tryptophan 5-Hydroxylation.- 2.2. 5-Hydroxytryptophl£ƒ