This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.
This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns.
Chapter 1: Introduction
Rick Russell
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Chapter 2: Comparative Analysis of the Higher-order Structure of RNA
Robin R. Gutell
Chapter 3: Graph Applications to RNA Structure and Function
Namhee Kim,? Katherine Niccole Fuhr,? Tamar Schlick
Chapter 4: Prediction and Coarse-Grained Modeling of RNA Structures
Zhen Xia, Pengyu Ren
Chapter 5: Studying RNA Folding Using Site-Directed Spin Labeling
Xiaojun Zhang, Peter Z. Qin
Chapter 6: The RNA Recognition Motif and Messenger RNA
Kathleen B Hall
Chapter 7: Memory Effects in RNA folding dynamics revealed by single molecule fluorescence
Rui Zhao, David Rueda
Chapter 8: An integrated picture of HDV ribozyme catalysis
Barbara L. Golden, Sharon Hammes-Schiffer, Paul R. Carey, Philip C. Bevil³$
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