Caveolins in Cancer Pathogenesis, Prevention and Therapy [Paperback]

Caveolins are important structural proteins of Caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of Caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers with also a mention of the novel role of Caveolin-3 in breast cancer.

Caveolins play an important role in the pathogenesis of multiple cancers. This volume focuses mainly on the importance of Caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers. It also studies the role of Caveolin-3 in breast cancer.

Preface.- Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression.- Caveolin-1 in Colon Cancer: the?Flexible Connection to Wnt Signaling.- Caveolin-1 and Pancreatic Ductal Adenocarcinoma.- Caveolin-1 in Brain Tumors.- The Role of Caveolin-1?in Skin Cancer.- Caveolins and Tumor Angiogenesis.- Caveolin-1 and Breast Cancer.- Caveolin-1 and Cancer-Associated Stromal Fibroblasts.- Index?

For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning little caves in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (caveolin-1, -2 and -3). As such, the current chapters illustrate the roles of caveolin-1 in breast, prostate, skin, colon, brain and pancreatic cancers, and highlight its specific contribution to tumor growth through epithelial and stromal interactions, as well as its involvement in angiogenesis. This book summarizes the existing literature and provides interl“0