Cell Entry by Non-Enveloped Viruses [Paperback]

The means by which non-enveloped viruses penetrate cellular membranes during cell entry remain poorly defined. Recent findings indicate several members of this group share a common mechanism of membrane penetration in which the virus particle undergoes programmed conformational changes, leading to capsid disassembly and release of small membrane-interacting peptides.A complete understanding of host cell entry by this minimal system will help elucidate the mechanisms of non-enveloped virus membrane penetration in general

This book examines the means by which non-enveloped viruses penetrate cellular membranes during cell entry. It will help elucidate the mechanisms of non-enveloped virus membrane penetration in general.

Preface.- Flock House Virus: A Model System for Understanding Non-enveloped Virus Entry and Membrane Penetration.- The Caliciviruses.- Picornaviruses.- From Touchdown to Transcription: The Reovirus Cell Entry Pathway.- Rotavirus Cell Entry.- Structures and Functions of Parvovirus Capsids and the Process of Cell Infection.- Cellular Entry of Polyomaviruses.- Adenovirus.- Subject Index

From the reviews:

This book contains detailed, up-to-date descriptions of cellular entry mechanisms of non-enveloped viruses, such as ssRNA viruses (nodavirus, picornavirus, calicivirus), dsRNA viruses (orthoreovirus, rotavirus), ssDNA viruses (parvovirus) and dsDNA viruses (polyomavirus, adenovirus). & The book is strongly recommended to established virologists, molecular and structural biologists, and young scientists working in these areas. (Ulrich Desselberger, Microbiology Today, May, 2011)Non enveloped viruses constitute an important class of medically significant pathogens. They encode their proteins in single (ss) and double strand (ds) RNA and DNA genomes and display a variety of sizes and structures. In this volume experts in the field provide up to date descriptions of many characteristics associated with the ssRNA noda, pil£,