Chromogranins Functional and Clinical Aspects [Paperback]

Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With.
This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With.
This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.Part 1: Introduction. 1. The chromogranins: Historical perspectives; K.B. Helle. 2. Chromogranins - Current concepts: Structural and functional aspects; D. Aunis, M.-H. Metz-Boutigue. Part 2: Intracellular Functions. 3. Signal-mediated sorting of chromogranins to secretory granules; H.-H. Gerdes, M.H. Gombik. 4. The condensed matrix of mature chromaffin granules: The soluble form of dopamine beta-hydroxyase is catalytically inactive; O. Terland, T. Flatmark. 5. Functional role of chromogranins: The ilsˆ