Chromosomal Alterations Methods, Results and Importance in Human Health [Hardcover]

The book helps the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and thus is of intense interest to all those interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

1 Human Chromosomes: Structural and Functional Aspects.- 2 DNA Lesions Induced by Ionizing Radiation.- 3 Effects of Ultraviolet Radiation on DNA.- 4 Double Strand Break Repair Mechanisms in Mammalian Cells.- 5 Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of Chromosome Aberrations.- 6 Targeted and Non-Targeted Induction of Chromosomal Rearrangements After Exposure to Ionizing Radiation.- 7 DNA Methylation Damage: Formation, Repair and Biological Consequences.- 8 Adducts, Sister-Chromatid Exchanges and Mutations Following Benzo[a]pyrene Exposure: a Rels.