Contemporary Nephrology Volume 5 [Paperback]

1:Water Transport across ADH-Sensitive Epithelia.- 1. Introduction.- 2. A Working Hypothesis.- 2.1. The Control Condition.- 2.2. The Action of ADH.- 3. Biochemical Aspects of the Mechanism of Action of ADH.- 3.1. ADH Receptors.- 3.2. Adenylate Cyclase.- 3.3. Cyclic AMP-Dependent Protein Kinase and Protein Phosphorylation.- 3.4. Modulators of the Hydrosmotic Response.- 4. Biophysics of Osmotic Water Flow.- 4.1. Water Transport by Solubility-Diffusion.- 4.2. Water Transport via Aqueous Pores.- 4.3. Water Transport via Narrow (Single-File) Pores.- 4.4. Effects of Unstirred Layers.- 4.5. Solvent Drag.- 5. Experimental Bases for the Pore Hypothesis of Water Permeation.- 5.1. Studies Based on Measurements of Transepithelial Osmotic Water Flow.- 5.2. Studies of Osmotic Water Permeability of Single Cell Membranes.- 5.3. The Pathway for Water Permeation.- 6. Role of the Cytoskeleton and Modulation of the Hydrosmotic Effect of ADH.- 7. Other Barriers to Osmotic Water Flow.- 8. Remaining Questions and Future Directions.- References.- 2:Renal Hemodynamics and Sodium Chloride Excretion.- 1. Renal Hemodynamics.- 1.1. Myogenic Mechanism.- 1.2. Tubuloglomerular Feedback Mechanism.- 1.3. Sensitivity of Tubuloglomerular Feedback Mechanism.- 1.4. Other Factors Controlling Renal Hemodynamics.- 2. Sodium Chloride Excretion and Regulation.- 2.1. Sodium Balance and Its Regulation.- 2.2. Renin-Angiotensin-Aldosterone System.- 2.3. Prostaglandins.- 2.4. Atrial Natriuretic Factor.- 3. Function of Discrete Nephron Segments.- 3.1. Proximal Tubule.- 3.2. Loop of Henle.- 3.3. Distal Tubule.- 3.4. The Collecting System.- References.- 3:Renal Metabolism.- 1. Introduction.- 2. Renal Substrate Utilization.- 2.1. Ketone Bodies.- 2.2. Serine Production.- 2.3. Citrate Transport in Metabolism.- 2.4. Kinins and Kallikrein.- 3. Effects of Acidosis on Renal Gene Expression.- 3.1. Introduction.- 3.2. Cellular Distribution of Adaptive Response.- 3.3. Altered Rates of Synthesis.- 3.4. Isolation of Specific cDlÄ