Cytoskeleton and Small G Proteins [Paperback]

Rho Family Proteins and Regulation of the Actin Cytoskeleton.- 1 Introduction.- 2 Structure and Regulation of Rho Family Proteins.- 2.1 Primary Structure of Rho Family Proteins.- 2.2 Expression of Rho Family Proteins.- 2.3 Post-Translational Modifications.- 2.4 Structural Analysis of Rho Family Proteins.- 3 Rho Family Proteins and Growth Factor-Induced Actin Reorganization.- 3.1 Rho.- 3.2 Rac.- 3.3 Cdc42.- 3.4 Other Rho Family Proteins.- 3.5 Links Between Different Rho Family Proteins:A Role in Cell Migration?.- 4 Rho Family Proteins and Cell Adhesion.- 4.1 Adhesion to the Extracellular Matrix.- 4.2 Intercellular Adhesions.- 5 Rho Family Proteins and Cytokinesis.- 6 Other Responses Regulated by Rho Family Proteins.- 6.1 Activation of the NADPH Oxidase and Phagocytosis.- 6.2 Secretion and Endocytosis.- 6.3 Mitogenesis and Transformation.- 7 Conclusions.- References.- Regulation of Cytoskeleton and Cell Adhesion by Rho Targets.- 1 Introduction.- 2 Regulation of Rho Activity.- 3 Functions of Rho.- 3.1 Formation of Stress Fiber and Focal Adhesion.- 3.2 Smooth Muscle Contraction.- 3.3 Neurite Retraction.- 3.4 Cytokinesis.- 3.5 Cell-Cell Adhesion.- 3.6 Actin Filaments Beneath Plasma Membrane.- 3.7 Other Functions.- 4 Rho Targets.- 5 Functions of Rho Targets.- 5.1 Rho-Kinase and MBS.- 5.2 mDia and Bnil.- 5.3 Other Rho Targets.- 6 Conclusion.- References.- Rnd Proteins: A New Family of Rho-Related Proteins That Interfere with the Assembly of Filamentous Actin Structures and Cell Adhesion.- 1 Introduction.- 2 Characterisation of Three New Members of the Rho Family.- 3 Biochemical Properties of Rndl: G-Proteins That Do Not Switch?.- 4 Expression in Tissues and Localization of Rndl in the Brain.- 5 Effects of Rndl Expression on the Formation of Actin Stress Fibers.- 6 Localization of Rndl in Swiss 3T3 Fibroblasts and Microinjected MDCK Cells.- 7 A Role for Rnd Proteins in Transformation?.- 8 Rnd Proteins and Targets of Farnesyl-Transferase Inhibitors.- 9 Conclusions.- ReferenclóÇ