Drug Resistance [Paperback]

Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time.
In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time.
In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.Introduction. I: Membrane Transport Mechanism. 1. P-Glycoprotein- Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal; J.M. Ford, et al. 2. Multidrug Resistance Associated with Overexpression of MRP; S.P.C. Cole, R.G. Deeley. II: Resistance to Alkylating Agents. 3. Mechanisms of Resistance to Alkylating Agents; P.G. Penketh, et al. 4. Glutathione S-Transferases; A. Raha, K.D. Tew. 5. The Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guanine; O.N. Ko?. III: Resistance to Microtubule Active Drugs. 6. Paclitaxel (TAXOL) Mechanisms of Resistance; A.M. Casazza, C.R. Fairchild. IlÄ