Endogenous ADP-Ribosylation [Paperback]

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:

??? Evolution and detection of endogenous ADP-ribosylation

??? ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)

??? ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)

The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

Part I: Evolution and Detection of Endogenous ADP-Ribosylation

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The natural history of ADP-ribosyltransferases and the ADP ribosylation system

L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer

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Identification and Analysis of ADP-ribosylated Proteins

Friedrich Haag and Friedrich Buck

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Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)

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Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine

Klaus Aktories, Gudula Schmidt and Alexander E. Lang

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Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein

Hideaki Tsuge, Toshiharu Tsurumura

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Regulation of nitrogenase by reversible mono-ADP-ribosylation

Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz WinklelC×