Immunotherapy for Infectious Diseases [Paperback]

In Immunotherapy for Infectious Disease, Jeffrey M. Jacobson, MD, and a panel of leading researchers review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function.In Immunotherapy for Infectious Disease, Jeffrey M. Jacobson, MD, and a panel of leading researchers review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function.Part I. Basic Principles of ImmunityHumoral ImmunityPeter L. NaraSome Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious DiseasesR. Pat Bucy and Paul GoepfertImmune Defense at Mucosal SurfacesProsper N. Boyaka and Jerry R. McGheePart II. Molecular Basis for ImmunotherapyProduction of Immunoglobulins and Monoclonal Antibodies Targeting Infectious DiseasesRenate Kunert and Hermann KatingerDendritic Cells: Their Role in the Immune Response to Infelc,