Inflammation in the Pathogenesis of Chronic Diseases The COX-2 Controversy [Hardcover]

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

PrefaceContributorsI. Historical PerspectivesCHAPTER 1. Anti-inflammatory Drugs in the 21st CenturyK. D. Rainsford, PhDII. Inflammatory Mechanisms of PathogenesisCHAPTER 2. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repairJ. Brice Weinberg, MD, Beverley Fermor, PhD, Farshid Guilak, PhDCHAPTER 3. obesity, inflammation, and vascular disease: The Role of the Adipose Tissue as an Endocrine OrganPaolo Calabro, MD, Edward T. H. Yeh, MDChapter 4. COX-2 and THE Inflammogenesis of CancerRandall E. Harris, MD, PhDCHAPTER 5. Role of COX-2 in Inflammatory AND DEGENERATIVE Brain DiseasesLuisa Minghetti, PhDIII. Inflammation and Cardiovascular Disease: the Coxib ControversyCHAPTER 6. Cardiovascular Effects of the Selective Cyclooxygenase-2 InhibitorsWilliam B. White, MDCHAPTER 7. COX-2 inhibitors and Cardiovascular RiskDaniel J. Salzberg, MD, Matthew R. Weir, MDCHAPTER 8. A BIOLOGICAL RATIONALE FOR THE CARDIOTOXIC EFFECTS OF ROFECOXIB: COMPARATIVE Analysis with other COX-2 Selective Agents and NSAIDsR. Preston Mason, PhD, Mary F. Walter, PhD, Charles A. Day, Robert F. Jacob, PhDIV. COX-2 Blockade in Cancer Prevention and TherapyCHAPTER 9. Cancer Chemoprevention by COX-2 Blockade: Results of Case Control Studies.Randall E. Harris, MD, PhD, Joanne Beebe-Donk, Galal A. Alshafie, MD, PhDCHAPTER 10. Strategies for Colon Cancer Prevention:Combination of Chemopreventive AgentsBandaru S. Reddy, DVM, PhDV. Inflammation and Neurodegenerative DiseaseCHAPTER 11. NSAIDs FOR THE Chemopreventlc-