Late Sequelae in Oncology [Paperback]

Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms.
The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.With contributions by numerous expertsIncreasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms.
The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.1 Individual Variation of Radio- and Chemosensitivity.- 1.1 Impact of Endogenous and Exogenous Factors on Radiation Sequelae.- 1.2 Endogenous and Exogenous Factors Modifying Chemosensitivity to Cytostatic Drugs.- 2 Neurotoxicity.- 2.1 Radiation-Induced Injury of the Central Nervous System.- 2.2 Cytostatic-Induced Central Nervous System Abnormalities.- 2.3 Radiation Myelopathy.- 2.4 Acute and Late Toxicity on Peripherall“I