Matrix Metalloproteinases and TIMPs [Paperback]

The matrix metalloproteinases (MMPs) are a large family of enzymes that breakdown different components of the extracellular matrix. Their catalytic activity is dependent a metal ion, usually zinc. This issue of theProtein Profilescovers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this, is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the 4 known classes of TIMP.Matrix metalloproteinaseswill therefore be an invaluable source of data for all researchers interested in MMPs and TIMPs.

Abbreviations; Introduction; MMP sequences; TIMP sequences; Three dimensional structures of the MMPs and TIMPs; Activation of the zymogen forms of MMPs; Protein substrates of the MMPs; Specificity requirements of the MMPs; Inhibition of the MMPs; Biological roles of the MMPs; Biological roles of the TIMPs; Bibliography; Protein sequence alignments