Medical Information Systems The Laboratory Module [Paperback]

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as endothelial and leukocyte microparticles and gene microarray technology to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.Table of ContentsDopamine and Glutamate in Psychiatric DisordersEdited by Werner J. Schmidt and Maarten E. A. ReithPart I. Dopamine1 Dopamine Receptor Alternative SplicingNeil M. Richtand, Laurel Pritchard, and Lique M. Coolen2 Dopamine receptorsKim A. NevePart II: Glutamate3 Glutamatergic Pathways: Their relevance for psychiatric diseasesYoland Smith4 Glutamate receptors: IonotropicDaniel T. Monaghan, Julia C.A. More, Bihua Feng, and David Jane5 Metabotropic Glutamate ReceptorsKrystyna OssowskaPart III: Schizophrenia6 Dopamine and SchizophreniaBart A. Ellenbroek7 Glutamate and Schizophrenia and the N-methyl-D-aspartate receptor hypofunction hypothesisStefan Bleich and Johannes Kornhuber8 Role of glycine in schizophreniaBeate D. KretschmerPart IV: Depression9 Dopamine and DepressionPhil Skolnick10 Glutamate and DepressionJoaquin Del Rio and Diana FrechillaPart V: Stress and aggression11 Dopamine, Glutamate and AggressionKlaus A. Miczek and Eric W. FishPart VI: Anxiety12 Glutamatergic Systems and AnxietyDavid N. StephensPart VII: Attention Deficit Hyperactivity Dislc~