Plasminogen Structure, Activation, and Regulation [Paperback]

I. Plasminogen: Structure and Regulation.- 1. Human Plasminogen: Structure, Activation, and Function.- 1. Introduction.- 2. Structure of Human Plasminogen.- 2.1. Primary Protein Structure.- 2.2. Gene Organization.- 3. Activation of Human Plasminogen.- 3.1. Activation by Physiological Activators.- 3.1.1. Urokinase-type Plasminogen Activator.- 3.1.2. Tissue-type Plasminogen Activator.- 3.2. Activation by Bacterial-derived Plasminogen Activators.- 3.2.1. Streptokinase.- 3.2.2. Staphylokinase.- 4. Targets for Plasmin Activity.- 5. Dysplasminogenemias and Phenotypic Manifestations.- 6. Conclusions.- References.- 2. Plasminogen Activators: Structure and Function.- 1. Introduction.- 2. Serine Proteases.- 3. Urokinase Plasminogen Activator, uPA.- 3.1. Serine Protease Domain.- 3.2. N-terminal Domains.- 3.2.1. KR Module.- 3.2.2. EG Module.- 4. Mechanisms Regulating uPA Function.- 4.1. Zymogen Activation.- 4.2. Zymogen Activity.- 4.3. Reciprocal Zymogen Activation.- 4.4. uPAR Stimulation of Plasminogen Activation.- 4.4.1. uPA and the Template Mechanism.- 4.4.2. Plasminogen and the Template Mechanism.- 4.5. Avian uPA, a Special Case?.- 5. Tissue Plasminogen Activator, tPA.- 5.1. Serine Protease Domain.- 5.2. N-terminal Domains.- 5.2.1. KR Modules.- 5.2.2. Fl-EG Supermodule.- 6. Mechanisms Regulating tPA Function.- 6.1. Zymogenicity.- 6.2. Fibrin Stimulation of Plasminogen Activation.- 6.2.1. tPA/fibrin Interaction.- 6.2.2. Vampire Bat Plasminogen Activator.- 6.3. Cellular Mechanisms Regulating tPA Activity.- 6.3.1. Endothelial Cells.- 6.3.2. Vascular Smooth Muscle Cells.- 6.3.3. Prion Protein.- 7. Concluding Remarks.- References.- 3. Plasminogen Activators Inhibitors.- 1. Plasminogen Activator Inhibitor-1.- 1.1. Natural and Recombinant PAI-1.- 1.2. Distinct Conformations of PAI-1.- 1.3. Target Specificity of PAI-1.- 1.4. PAI-1 in Patho-Physiological Processes.- 1.4.1. PAI-1 and Cardiovascular Disease.- 1.4.2. PAI-1 and Cancer.- 1.5. PAI-1 Inhibitors and their Binding Sites.- 2.l£p