Principles of Receptor Research [Paperback]

1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs.- 1. Introduction.- 2. Characteristics of the Blood-Brain Barrier.- 2.1. Specific Activity of the Blood-Brain Barrier.- 2.2. Breakdown of the Blood-Brain Barrier.- 2.3. The Brain-CSF Barrier.- 3. Bypassing the Blood-Brain Barrier: Principles.- 4. Pharmacological Approach to the Internal or External Surface of the Brain.- 4.1. Drugs Applied to the Surface of the Cortex.- 4.2. Administration of a Drug into the Cerebral Ventricles.- 4.3. Perfusion of Brain Surfaces.- 5. Drugs Administered to the Brain Parenchyma.- 5.1. Injection of Solution.- 5.2. Depositing a Chemical in Crystalline Form.- 5.3. Isolated Perfusion with Push-Pull Cannulae.- 6. Concluding Comment.- 7. References.- 2 Microiontophoretic Application of Drugs onto Single Neurons.- 1. Introduction.- 2. Basic Principles.- 2.1. Spontaneous Efflux of Active Material from Microelectrodes.- 2.2. Release of Ionized Substances During Passage of Iontophoretic Current.- 2.3. Electro-osmosis.- 2.4. Microinjection.- 3. Dispersal of Iontophoretically Applied Substances Within the Brain.- 3.1. Theoretical Curves Based on Models of Diffusion.- 3.2. Tissue Uptake Mechanisms and Drug Redistribution.- 4. Conclusions.- 5. References.- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects.- 1. Introduction.- 2. Selection of Animal Species.- 3. Acute Experiments.- 4. Chronic Implantation of Electrodes.- 5. Recording Procedures.- 5.1. Experiments in Animals with Chronic Implants.- 5.2. Human Studies.- 5.3. Derivations.- 5.4. Amplifiers.- 5.5. Paper Records.- 5.6. Magnetic Tape Recording.- 6. Methods of Analyzing and Quantifying the EEG.- 6.1. Hand Analysis.- 6.2. Integration.- 6.3. Frequency Analysis.- 6.4. Spectral Analysis.- 6.5. Correlation Procedures.- 7. Sensory Evoked Response Analysis.- 7.1. Visual Evoked Responses.- 7.2. Somatosensory Evoked Responses.- 7.3. Auditory Evoked Responses.- 8. Focal Electrical Stl£)