Over the past decades, knowledge about the cellular and molecular basis underlying the visual process has remarkably increased. In Retinal Degeneration: Methods and Protocols, expert researchers in the field provide a guide of relevant and state-of-the-art methods for studying retinal homeostasis and disease. These include methods and techniques for addressing cell culture systems and animal models of disease, their generation, their phenotypic and molecular characterization as well as their use in therapeutic approaches to the retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Retinal Degeneration: Methods and Protocols aids scientists in continuing to study the? cutting-edge techniques of retinal cell biology in health and disease.
This Methods in Molecular Biology book offers methods for studying retinal homeostasis and disease, including cell culture systems and animal models of disease, their generation, phenotypic and molecular characterization and use in therapeutic approaches.
Part I: Human Genetics
1. Identification and Analysis of Inherited Retinal Disease Genes
Kornelia Neveling, Anneke I. den Hollander, Frans P.M. Cremers, and Rob W.J. Collin
Part II : Mouse Models
2. Mouse Models for Studies of Retinal Degeneration and Diseases
Bo Chang
3. Retinal Fundus Imaging in Mouse Models of Retinal Diseases
Anne F. Alex, Peter Heiduschka. Nicole Eter
4. Functional Phenotyping of Mouse Models with ERG
Naoyuki Tanimoto, l#S
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