Stem Cell Biology in Neoplasms of the Central Nervous System [Hardcover]

This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.
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The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.

1. Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain?
Vivian Capilla-Gonzalez, Emily Lavell, Alfredo Qui?ones-Hinojosa, Hugo Guerrero-Cazares

2. The SVZ and Its Relationship to Stem Cell Based Neuro-oncogenesis
Yael Kusne and Nader Sanai

3. Isolation and characterization of stem cells for human central nervous system malignancies
Imad Saeed Khan and Moneeb Ehtesham

4. The role of stem cells in pediatric central nervous system malignancies
Branavan Manoranjan, Neha Garg, David Bakhshinyan, Sheila K. Singh

5. Laboratory models for central nervous system tumor stem cell research
Imad Saeed Khan and Moneeb Ehtesham

6. Radiation Therapy for Glioma Stem Cells
Anthony E Rizzo, B.A. and Jennifer S. Yu

7. Chemoresistance and chemotherapy targeting stem-like cells in maliglÓ$