Systems Analysis of Chromatin-Related Protein Complexes in Cancer [Hardcover]



Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie ?environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic code is considered a key challenge in biomedical research.

Chromatin structure and function are modified by protein complexes, causing genes to be turned on or off and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized.

To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines ?- namely, the readers, writers and erasers of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery.

What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

This book identifies RNA molecules associated with various chromatin-modifying machines. It explores the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells).Preface.- Systematic proteomic analysis of histone demethylating enzymes linked to cancer.- Histone methylating protein complexes in cancer.- Chromatin protein-protein interaction networks linked to cancer.- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition.- Transcription factories and global chromatin (enhancer) interactions in cancer.- Long ncRNlS8