The advances of live cell video imaging and high-throughput technologies for functional and chemical genomics provide unprecedented opportunities to understand how biological processes work in subcellular
and multicellular systems. The interdisciplinary research field of Video Bioinformatics is defined by Bir
Bhanu as the automated processing, analysis, understanding, data mining, visualization, query-based
retrieval/storage of biological spatiotemporal events/data and knowledge extracted from dynamic images
and microscopic videos. Video bioinformatics attempts to provide a deeper understanding of continuous
and dynamic life processes.
Genome sequences alone lack spatial and temporal information, and video imaging of specific molecules
and their spatiotemporal interactions, using a range of imaging methods, are essential to understand
how genomes create cells, how cells constitute organisms, and how errant cells cause disease. The book
examines interdisciplinary research issues and challenges with examples that deal with organismal dynamics,
intercellular and tissue dynamics, intracellular dynamics, protein movement, cell signaling and software
and databases for video bioinformatics.
Topics and Features
Covers a set of biological problems, their significance, live-imaging experiments, theory and
computational methods, quantifiable experimental results and discussion of results.
Provides automated methods for analyzing mild traumatic brain injury over time, identifying injury
dynamics after neonatal hypoxia-ischemia and visualizing cortical tissue changes during seizure
activil£+
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