Long Circulating Liposomes Old Drugs, New Therapeutics [Paperback]

This book provides an up-to-date evaluation of clinical aspects of newly available long-circulating liposome formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.1. Long Circulating Liposome Therapeutics: From Concept to Clinical Reality.- 2. Oncologic Agents in Sterically Stabilized Liposomes: Basic Considerations.- 3. Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations.- 4. Long Circulating Liposome-Encapsulated Tumor Necrosis Factor in the Treatment of Solid Tumors.- 5. Therapy of Human Carcinoma Xenografts with Doxorubicin Encapsulated in Sterically Stabilized Liposomes (DOXIL?): Efficacy and Safety Studies.- 6. Design and Development of Long Circulating Liposomal Daunorubicin for In Vivo Targeting of Solid Tumors: DaunoXome?.- 7. Enhancement of Doxorubicin by Encapsulation in Long circulating Thermosensitive Liposomes Combined with Local Hyperthermia.- 8. Liposomal Localization and Chemotherapy for AIDS-Related Kaposis Sarcoma.- 9. Pegylated-Liposomal Doxorubicin (Doxil?) in the Treatment of AIDS-Related Kaposis Sarcoma.- 10. DaunoXome? (Liposomal Daunorubicin) for First-Line Treatment of Advanced, HIV-Related Kaposis Sarcoma.- 11. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors.- 12. Antibacterial Therapy with Sterically Stabilized Liposome Formulations.- 13. AmBisome?: Long Circulating Liposomal Formulation of Amphotericin B.- 14. Steric Stabilization of Liposomes Containing Amphotericin B: A Future Direction in Antifungal Therapy?.- 15. CllÓ3