The Eukaryotic Replisome a Guide to Protein Structure and Function [Hardcover]

High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

Preface?

1. Composition and dynamics of the eukaryotic replisome: a brief overview; Stuart A. MacNeill
1.1 Introduction
1.2 Replication origins and the origin recognition complex
1.3 Formation of the pre-RC at origins
1.4 The replisome progression complex
1.5 The replicative polymerases
1.6 Sliding clamp and clamp loader complexes
1.7 Okazaki fragment processing
1.8 Model systems for the studying eukaryotic replication
?? 1.8.1 SV40
?? 1.8.2 Yeast
?? 1.8.3 Xenopus
?? 1.8.4 Archaea
?? 1.8.5 Other model systems
1.9 Conclusions
Acknowledgements
References

2. Evolutionary diversification of eukaryotic DNA replication machinery; Stephen J. Aves, Yuan Liu and Thomas A. Richards
2.1 Introduction
2.2 Eukaryotic diversity
2.3 Conservation of replisome proteins
2.4 Indispensable replisome proteins
2.5 Replisome proteins present in all eukaryotic supergroups
2.6 Replisome proteins not preslƒ.