The Tumor Immunoenvironment [Hardcover]

Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.This book examines immune cell functioning in cancer, with a focus on both experimental animal results and human clinical trials.

Preface ?Dmitry I. Gabrilovich?

Introduction

Role of the immunological environment in cancer initiation, development and progression
Anatoli Malyguine, Viktor Umansky and Michael R. Shurin?

Part I?? Tumor Microenvironment and Immunoenvironment

The metastatic microenvironment
Shelly Maman and Isaac P. Witz?

Tumor infiltration by immune cells: pathologic evaluation and a clinical significance
Dmitri W. Gutkin

Immunologic interpretation of cancer biology: impact on clinical outcome
Maria Libera Ascierto, Ena Wang and Francesco M Marincola???????????????????????

Part II? Developmental Characteristics of the Tumor ImmunoEnvironment??

Development of antitumor cellular immunity
M.J.P. Welters and S.H. van der Burg??

The versatile world of inflammatory chemokines in cancer
Tal Leibovich-Rivkin, Yaeli Lebel-Haziv, Shalom lcÏ