Drug Stability for Pharmaceutical Scientists [Paperback]

Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries.

• Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material
• Provides answers and explanations to test your knowledge
• Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more
• Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability

I. Principles of drug degradation (the solution kinetics and mathematical treatment): 1.?Zero, first, second and third order reactions 2.?Complex reactions (e.g. reversible reactions, parallel reactions, consecutive reactions, steady state, enzyme kinetics etc.) 3.?Effect of temperature (e.g. Arrhenius, Q10-values, Collision theory, Transition state theory, Eyring equation etc.) 4.?Effect of pH (Specific acid/base catalysis, pH-rate profiles) 5.?Effect of buffer salts (General acid/base catalysis or buffer catalysis) 6.?Ionic strength 7.?Solvent effects (e.g. dielectric constant) 8.?Surface active compounds (micelle effect) 9.?Effect of complexation (e.g. cyclodextl+