Half a Century of Free Radical Chemistry [Paperback]

This book describes a lifetime devoted to creative chemistry in the service of all mankind.An account of the Nobel Laureate author's exhaustive work with the chemistry of organic free radicals and the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds.An account of the Nobel Laureate author's exhaustive work with the chemistry of organic free radicals and the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds.This book describes the work of Nobel Laureate Derek Barton on the chemistry of organic free radicals, and the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds. It begins with a mechanistic study of industrial significance on the pyrolysis of chlorinated alkanes. It continues with a theory on the biosynthesis of phenolate derived alkaloids involving phenolate radical coupling. The book then describes the work on nitrite photolysis (Barton reaction), which involved the invention of new radical chemistry leading to a simple synthesis of the important hormone, aldosterone. It also describes another new reaction extended to carboxlic acids that provides carbon, nitrogen, oxygen and other radicals under mild conditions. A final chapter summarizes recent applications of thiocarbonyl group derived radical reactions by other authors.1. The pyrolysis of chlorinated hydrocarbons; 2. Phenolate radical coupling in synthesis and biosysnthesis; Pummerer's ketone; 3. Nitrite photolysis (the Barton Reaction); 4. Radical deoxygenation(the reaction of Barton and Mc Combie); 5. Disciplined radicals and disciplinary radical reactions (Barton decarboxylation); 6. Some recent synthetic applications of Barton radical methodologies.' & a very useful book both for the specialist radical fraternity and for those engaged in modern organic synthesis & (will) inspire young scientists interested ilÓ$