The Jak-Stat Pathway in Hematopoiesis and Disease [Hardcover]

This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.1. Jaks and Normal Hematopoiesis; T. Nosaka. 2. Jak3-Dependent Pathways in Hematopoiesis and SCID; N.A. Cacalano, J.A. Johnston. 3. Stat Activation by Src, Fes and Btk Tyrosine Kinases; T.E. Smithgall. 4. Stats and Hematopoiesis; A.C. Ward. 5. Stat Signaling in Leukemia: Implications for Pathogenesis and Treatment; D.A. Frank. 6. The Role of the Jak-Stat Pathway in Hematopoiesis and Immune Responses in Drosophila; E.A. Bach, N. Perrimon. 7. SOCS Proteins in Hematopoiesis; S. Nicholson, W. Alexander. Index.