Jak-Stat Signaling From Basics to Disease [Hardcover]

JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

This, the first comprehensive treatment of the subject in years, offers detailed insights into the latest basic and clinical developments in the field. It explains JAK-STAT signaling under physiological conditions and discusses treatment of aberrant pathways.

The continuing fascination with Jaks and Stats: An introduction .- Regulation of JAKs: Insights gleaned from the functional protein domains .- Nuclear functions of the Janus Kinases .- Self-association of STAT proteins from monomers to paracrystals .- How Stats interact with the molecular machinery of transcriptional activation .- Nongenomic Functions of STAT3 .-Evolution of Jak and Stat proteins .- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses .- Slƒ&