Key Clinical Trials in Erectile Dysfunction [Paperback]

Contained within this short volume are some of the Key Clinical Trials relating to the medical treatment of erectile dysfunction (ED). In an attempt to understand the potential significance, a critique of the studies strengths and weaknesses is included as well as a diagrammatic summary of the trial design and key results. Most of the studies have appeared in peer group reviewed journals and each trial included has been done so on the basis of the influence it will have on the treatment of ED. With the recent launch and continuing developments of new drugs in this field, the management of ED has become an increasingly important aspect of urological practice. It is estimated that over 20 million men in Europe alone suffer at some time in their life from ED. This is the first book to bring together in a single volume a critical review of all the major trials in ED.

It will be an essential reference for both clinicians and research workers in urology, sexual dysfunction and related disorders.

The Earliest Carefully Controlled Clinical Trial Evaluating Oral Pharmacotherapy (Yohimbine) in ED.- A Description of the Pioneering Work That Led to the First Approved Agents for ED: Giles Brindley, the Needle, and the Penis (Phenoxybenzamine).- The Pivotal Study Showing That Intracorporal Injection of Vasoactive Agents (Papaverine or Phenoxybenzamine) Was Effective Pharmacotherapy.- The First Placebo-Controlled Study on the Benefits of Intracorporal Administration of Vasorelaxant Agents to ED Patients (Papaverine/Phentolamine Combination).- Representative Study on the Use of Yohimbine in the Treatment of Organic ED.- Defining the Therapeutic Ratio for Intracavernosal Administration of Prostaglandin E1 (Alprostadil).- An Elegant Long-Term Trial Assessing the Clinical Profile of Intracavernosal Prostaglandin E1 (Alprostadil).- Evaluation of Novel Combination (Vasoactive Intestinal Polypeptide and Phentolamine) as Intracavernl£&