Kynurenine and Serotonin Pathways Progress in Tryptophan Research [Paperback]

Proceedings of the International Study Group for Tryptophan Research: Sixth International Meeting, held in Baltimore, Maryland, May 9--12, 1989Session I. Tryptophan and its Metabolites: Chemical and Analytical Issues.- Retro-, Intro- and Perspectives of Trypto-Fun.- Tryptophan and Related Alkaloids.- Stability of Tryptophan in Peptides Against Oxidation and Irradiation.- Mass Spectrometric Determinations of Tryptophan and its Metabolites.- Signal-to-Noise Optimization of HPLC-Fluorometric Systems and their Application to the Analysis of Indoles.- Brain Indole Metabolism Assessed Using in vivo Dialysis.- Sub-Picogram Determination of Serotonin Using HPLC with Electrochemical Detection for Microdialysis Studies of Serotonin Release.- Session II. Tryptophan Metabolism: Serotonin and Melatonin.- Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brain.- Autoradiographic Studies of 5HT2 Receptors.- Ambivalence on the Multiplicity of Mammalian Aromatic L-Amino Acid Decarboxylase.- Interrationships of DNA Cycles and Melatonin Synthesis.- Regulation of Melatonin Synthesis in the Ovine Pineal Gland.- Melatonin Synthesis: Multiplicity of Regulation.- Session III. Tryptophan Metabolism: Kynurenines.- The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase.- Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues.- Relationships Between Pteridine Synthesis and Tryptophan Degradation.- Quinolinic acid and Kynurenic acid in the Mammalian Brain.- Kynurenate Forming Enzymes in Liver, Kidney and Brain.- Regulation of Pyridine Nucleotide Coenzyme Metabolism.- Session IV. Biological Effects: Serotonin and Melatonin.- Serotonin: Its Role and Receptors in Enteric Neurotransmission.- Mechanisms of Serotonergic Affect Control.- Neuroendocrine Responses to L-Tryptophan as an Index of Brain Serotonin Function: Effect of Weight Loss.- Melatonin Receptors in the Central Nervous System.- Melatonin IntelS.