Linkage Disequilibrium and Association Mapping Analysis and Applications [Paperback]

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In Linkage Disequilibrium and Association Mapping: Analysis and Applications, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike.

The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.

LINKAGE DISEQUILIBRIUM AND ASSOCIATION MAPPING: ANALYSIS AND APPLICATIONS.Chapter 1. Linkage disequilibrium and association mapping - an introduction. (Andrew Collins).Chapter 2. A history of association mapping (Newton E Morton) .Chapter 3. Linkage disequilibrium maps and location databases.(William Tapper).Chapter 4. LDMAP: The construction of high-resolution linkage disequilibrium maps of the human genome. (Kuo T-Y, Lau W, Collins A).Chapter 5. Linkage disequilibrium as a tool for detecting the signatures of selection. (Sarah Ennis) .Chapter 6. The genetic basislc8