Lipid-mediated Protein Signaling [Paperback]

This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.

Preface

1. Sphingomyelin and its role in cellular signaling; Mahua Chakraborty and Xian-Cheng Jiang

2. The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains; Jacques Fantini and Nouara Yahi

3. The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition; Shuyan Xiao, Carla V. Finkielstein, and Daniel G. S. Capelluto

4. Phosphoinositides and PDZ Domain Scaffolds; Anna Maria Wawrzyniak, Rudra Kashyap and Pascale Zimmermann

5. PtdIns(4)P signalling and recognition systems; Marc Lenoir and Michael Overduin

6. PtdIns(4,5)P₂-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism; Arne Gericke, Nicholas R. Leslie, Mathias L?sche, and Alonzo H. Ross

7. Role of Phosphatidylinositol 3,4,5-trisphosphate in Cell Signaling; Robert D Riehle, Sinziana Cornea and Alexei Degterev