Macro Roles for MicroRNAs in the Life and Death of Neurons [Paperback]

The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.

Profiling the microRNAs by Kenneth S. Kosik, Thales Papagiannakopoulos, Na Xu, Kawther Abu-Elneel, Tsunglin Liu and Min Jeong Kye.- The Wide Variety of miRNA Expression Profiles in the Developing and Mature CNS by Marika Kapsimali.- Interactions Between microRNAs and Transcription Factors in the Development and Function of the Nervous System by David J. Simon.- A microRNA Feedback Circuit in Midbrain Dopamine Neurons by Asa Abeliovich.- Fine-Tuning mRNA Translation at Synapses with microRNAs by Gerhard M. Schratt.- Neuronal P-bodies and Transport of microRNA-Repressed mRNAs by Florence Rage.- Crosstalk between microRNA and Epigenetic Regulation in Stem Cells by Keith Szulwach, Shuang Chang and Peng Jin.- microRNAs in CNS Development and Neurodegeneration: Insights from Drosophila Genetics by Stephen M. Cohen.- Drosophila as a Model for Neurodegenerative Disease: Roles of RNA Pathways in Pathogenesis by Nancy M. Bonini.- MicroRNAs in Sporadic Alzheimers Disease and Related Dementias by S?bastien S. H?bert, Wim Mandemakers, Aikaterini S. Papadopoulou and Bart De Strooper.- microRNA Dysregulation in Psychiatric Disorders by Bin Xu, Joseph A. Gogos and Maria Karayiorgou.- Subject Index.

The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple l“Å