The Major Histocompatibility System in Man and Animals [Paperback]

Introductory Remarks The Major Histocompatibility System..- 1 The Major Histocompatibility System in Man..- 1. Introduction.- 2. Serologically Defined Histocompatibility Antigens.- 2.1 Historical Remarks.- 2.2 Serology.- 2.3 The Definition of HLA Antigens.- 2.4 The Genetic Organization of HLA-A, B, and C Antigens.- 2.5 Phenotype and Gene Frequencies.- 2.6 Haplotype Frequencies.- 2.7 Linkage Disequilibrium.- 2.8 Cross-Reactivity.- 3. Lymphocyte-Defined Antigens.- 3.1 Historical Remarks.- 3.2 Genetics of MLC.- 3.3 Primed Lymphocyte Typing.- 4. Serological Definition of B-Cell-Specific Alloantigens.- 4.1 Historical Remarks.- 4.2 Methodology.- 4.3 Genetics of B-Cell Alloantigens.- 5. Cell-Mediated Cytotoxicity.- 5.1 Methodology.- 5.2 Genetics of CML.- 6. Tissue Distribution of HLA Antigens.- 6.1 HLA-A and -B Antigens.- 6.2 HLA-D or Lymphocyte Activating Determinants.- 7. Surface Distribution of HLA Antigens.- 8. Biochemistry.- 8.1 Localization of H Antigens and Source for Their Purification.- 8.2 Assays Monitoring Activity of Soluble HLA Antigens.- 8.3 Extraction Procedures.- 8.4 HLA-A and -B Antigens in the Serum and Urine.- 8.5 HLA-C Antigens.- 9. HLA-D Antigen (B-Cell-Specific, HLA-D Locus-Linked Gene Products).- 10. Linked Loci and Mapping of the HLA Region.- 11. HLA and Transplantation.- 12. HLA-Disease Associations.- 12.1 Historical Remarks.- 12.2 Statistical Considerations.- 12.3 Groups of HLA-Associated Diseases.- 12.4 Models of HLA-Disease Associations.- 12.5 Genetic Considerations.- References.- 2 The Major Histocompatibility System of Subhuman Primate Species..- 1. Introduction.- 2. RhL-A, MHS of Rhesus Monkeys.- 2.1 Detection of Tissue Alloantigens.- 2.2 Biochemistry.- 2.3 Histocompatibility.- 2.4 MHC-Linked Immune Responses.- 2.5 Genetic Organization of the RhL-A System.- 3. ChL-A, the MHS of Chimpanzees.- 3.1 Detection of Tissue Alloantigens.- 3.2 Histocompatibility.- 3.3 Genetic Organization of the ChL-A System.- 4. Tissue Antigens of Other Subhuman Prilób