The major changes in strategy and structure in MNEs increasing levels of global integration, innovation by design, new network structures, outsourcing of major value-chain activities, E-commerce and the backlash against globalization. This special issue includes an overview of the integration-responsiveness framework. Multinational Strategy and Structure: A Review and Research AgendaA New Perspective on the Integration-Responsiveness Pressures Confronting Multinational FirmsMultinationals, Reverse Diffusion and National Business SystemsGlobal Versus Multidomestic: Culture's Consequences on InnovationContextual Moderating Effects and the Relationship of Firm-Specific Resources, Strategy, Structure and Performance among Japanes Multinational EnterprisesManaging International Technology Transfer Risk: Alternatives and Complements to Ownership StructureIncreasing the levels of global integrationDavid Brock, Senior Lecturer, Department of Business Administration, Ben-Gurion University, Beer-Sheva, Israel. Julian Birkinshaw, Associate Professor, Strategic and International Management, London Business School, London, UK. Multinational corporations (MNCs) are frequently pictured as being at the vanguard of global integration.They face strong incentives to maximize economies of scale in research and development, purchaising, production and marketing, and encounter low barriers in the dissemination of technologies and best practices. This special issue brings together various papers that focus on different aspects of the tension between global and local within MNCs.Auswirkungen multinationaler Strategien und StrukturenThe major changes in strategy and structure in MNEs increasing levels of global integration, innovation by design, new network structures, outsourcing of major value-chain activities, E-commerce and the backlash against globalization. This special issue includes an overview of the integration-responsiveness framework.l3u