Mechanisms of Transcription [Paperback]

Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. A collection of distinguished authors draws together the underlying mechanisms involved in the process of transcription. This includes RNA polymerase function and its interaction with promoter sequences, and the structures of the various components on the transcriptional machinery. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. A collection of distinguished authors draws together the underlying mechanisms involved in the process of transcription. This includes RNA polymerase function and its interaction with promoter sequences, and the structures of the various components on the transcriptional machinery. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.Fundamental Aspects of T7 RNA Polymerase Structure and Mechanism.- Transcription by T7 RNA Polymerase.- Pribnow Box Recognition and Melting by Escherichia coli RNA Polymerase.- Extended 10 Promoters.- Promoter Selectivity Control of RNA Polymerase.- The Effect of High Pressure on Transcription and on the Structure and Activity of E. coli RNA Polymerase.- Ribosomal RNA Promoter-RNA Polymerase Interactions and rRNA Transcription in Escherichia coli.- Synergistic Activation of Transcription in E. coli.- Indirect Effects of DNA Sequence on Transcriptional Activation by Prokaryotic DNA Binding Proteins.- Transcriptional Activation by a Topologically Linkable Protein: Forging a Connection Between Replication and Gene Activity.- Translocation of DNA-Dependent E. coli RNA Polymerase During RNA Synthesis.- Stabilisation of DNA Microlols+