Mechanosensitivity of the Heart [Paperback]

This timely review of heart mechanosensitivity examines tissues at the molecular, biological, bio-physical, physiological and pharmaceutical levels. New insight on the electromechanical properties of cardiac tissue is supported with experimental results.

Foreword by Vadim Fedorov; Editorial, Andre Kamkin and Irina Kiseleva; List of Contributors; Part I: Molecular Mechanisms of Mechanotransduction in Cardiac Cells - 1 Titin and Titin-associated Proteins in Myocardial Stress-sensing and Mechanical Dysfunction, Wolfgang A. Linke; 2 Mechanical Stretch-Induced Reorganization of the Cytoskeleton and the Small GTPase Rac-1 in Cardiac Fibroblasts, Wayne Carver and John W. Fuseler; 3 Molecular Signaling Mechanisms of Myocardial Stretch: Implications for Heart Disease, Hind Lal, Suresh K. Verma, Honey B. Golden, Donald M. Foster, April M. Holt and David E. Dostal; 4 Mechanical Stress Induces Cardiomyocyte Hypertrophy through Agonist-independent Activation of Angiotensin II Type 1 Receptor, Hiroshi Akazawa and Issei Komuro; Part II: Mechanically Induced Potentials and Currents of the Cardiac Cells in Healthy and Diseased Myocardium - 5. Mechanostransduction in Cardiac and Stem-Cell Derived Cardiac Cells, Jeffrey G. Jacot, Anna J. Raskin, Jeffrey H. Omens, Andrew D. McCulloch and Leslie Tung; 6 Stretch-activated Channels in the Heart: Contribution to Cardiac Performance, Marie-Louise Ward and David G. Allen; 7 Effects of Applied Stretch on Native and Recombinant Cardiac Na+ Currents, Umberto Banderali, Robert B. Clark, Catherine E. Morris, Martin Fink and Wayne R. Giles; 8 Mechanosensitive alterations of action potentials and membrane currents in healthy and diseased cardiomyocytes: Cardiac tissue and isolated cell, Ilia Lozinsky and Andre Kamkin; 9 The Role of Mechanosensitive Fibroblasts in the Heart: Evidence from Acutely Isolated Single Cells, Cultured Cells and from Intracellular Microelectrode Recordings on Multicellular Preparations from Healthy and Disl#2